Cambridge is a city in Guernsey County, Ohio, United States, and its county seat. The population was 10,089 at the 2020 census. It lies in …Cambridge is a city in Guernsey County, Ohio, United States, and its county seat. The population was 10,089 at the 2020 census. It lies in the Appalachian Plateau of the Appalachian Mountains in southeastern Ohio. It is the principal city of the Cambridge micropolitan area and is located adjacent to the intersection of Interstates 70 and 77.
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