The 49ers are headed back to the playoffs after blowing out the Cardinals for the second time this season, capping their 10-game win streak with a 38-13 rout.

When the Cardinals last played the 49ers, Conner was a problem rushing for 86 yards, averaging 4.5 yards per carry. With gone, the 49ers will have a much easier matchup defending.

The San Francisco 49ers have officially clinched the NFC West division title after beating down the Arizona Cardinals. It wasn't a close game at all despite how the final score is presented.

The Cardinals dominated the second half today against the 49ers, pulling off a road upset in a game that may prove to have major ramifications in the NFC West race. Cardinals quarterback Kyler ...

The San Francisco 49ers defeated the Arizona Cardinals 38-10 in Mexico City on Monday. Stay tuned into this live blog from The Athletic for breaking news, updates, inactives, scores and more from ...

Kyler Murray threw for 242 yards and four touchdowns, two to Greg Dortch, and the Arizona Cardinals beat the injury-depleted San Francisco 49ers 47-24. Latest U.S.

When the Cardinals last played the 49ers, Conner was a problem rushing for 86 yards, averaging 4.5 yards per carry. With gone, the 49ers will have a much easier matchup defending.

For the 49ers, there were some positive signs: Brandon Aiyuk had a big game, and Jordan Mason continued to play well in place of the injured Christian McCaffrey. But it ultimately wasn’t enough. The ...