The gradient created by this drives hydrogen back through the membrane, through ATP synthase. As this happens, the enzymatic activity of ATP synthase synthesiszes ATP from ADP. Mitochondria are ...

Found inside mitochondria, ATP synthase generates the energy storage molecule adenosine triphosphate, which the cells of all living things use for fuel. The enzyme generally looks similar in shape ...

TMC207 inhibits the proton pump of mycobacterial ATP synthase, a critical enzyme in ... but early bactericidal activity is probably preserved. Mouse model studies suggest a synergistic ...