From caffeine to penicillin, natural products have become a mainstay in modern society, and are used for numerous ...

"In such gene clusters, genes encoding for enzymes that coordinate the subsequent steps in a biosynthetic pathway are organized in close proximity to each other," explains Becker. "This ensures ...

For instance, orphan gene clusters that correspond to biosynthetic loci for which the metabolite is not known are commonly found in the genomes of microorganisms. “It is hard to estimate [how ...

The drugs were found to upregulate a cluster of genes encoding cholesterol and fatty acid biosynthetic enzymes, the transcription of which is controlled by the sterol regulatory element-binding ...

From caffeine to penicillin, natural products have become a mainstay in modern society and are used for numerous applications ...

A new study demonstrates how plants of the nightshade family produce pharmaceutically valuable compounds and how this biosynthesis is epigenetically regulated. Plants are masters at producing a ...