These data both confirm and extend prior knowledge about the base preferences conferred by individual residues within the C2H2-ZF domain 1, motivating us to develop an improved recognition code model.

Researchers at the University of Toronto have shown that an important class of DNA-binding factors can also bind to RNA, regulating gene expression through various mechanisms. The study significantly ...

C2H2 zinc finger proteins constitute one of the largest families of transcription factors in plants, characterised by conserved motifs of two cysteine and two histidine residues that coordinate a zinc ...