Nature

Cytotoxicity of thymoquinone alone or in combination with cisplatin (CDDP) against oral squamous cell carcinoma in vitro

Cisplatin (CDDP) is potent anticancer agent used for several tumor types. Thymoquinone (TQ) is naturally occurring compound drawing great attention as anticancer and chemomodulator for chemotherapies.
Nature

JMJD2C mediates the MDM2/p53/IL5RA axis to promote CDDP resistance in uveal melanoma

Chemotherapy resistance poses an obstacle for effective treatment of uveal melanoma. In this study, we aim to investigate the effects of jumonji domain containing 2C (JMJD2C)-mediated mouse double ...
Medscape

Weekly Cisplatin New Standard in Postop Head and Neck Cancer

For the first time, weekly cisplatin plus radiotherapy (CDDP+RT) has been shown to be not only less toxic than dosing once every three weeks but also achieves better outcomes in patients with ...
ascopubs.org

Neuroprotective effect of reduced glutathione on cisplatin-based chemotherapy in advanced gastric cancer: a randomized double-blind placebo-controlled trial.

Surgical/pathologic-stage migration confounds comparisons of gastric cancer survival rates between Japan and Western countries. Fifty patients with advanced gastric cancer treated with a weekly ...
ascopubs.org

Phase I/II study of cisplatin (CDDP) and docetaxel (DOC) with concurrent chest radiotherapy followed by full dose of consolidation chemotherapy with CDDP/DOC in locally ...

Intrapatient dose escalation to 800 mg/m2 pemetrexed is safe and feasible in patients with advanced non-small cell lung cancer (NSCLC) who have had prior chemotherapy No significant financial ...