Owing to its highly polymorphic nature and major contribution to the metabolism and bioactivation of numerous clinically used drugs, CYP2D6 is one of the most extensively studied drug-metabolizing ...

In recent years, scientists discovered that an enzyme called CYP2D6 could possibly predict whether a patient would respond to the drug. Small studies aimed at confirming the predictive link, however, ...

—New research uncovers a possible link between CYP2D6 activity and the development of tardive dyskinesia in certain patients taking antipsychotics. Reviewed by Nicole Foubister, Clinical Assistant ...

Accurate prediction of CYP2D6 activity from genotype data is of utmost importance as CYP2D6 pharmacogenetic (PGx) testing is increasingly used to guide drug therapy. However, given the complexity of ...

Nursing home residents are commonly prescribed painkillers and antidepressants to manage comorbid pain and depressive disorders. This study found that residents prescribed tramadol and a ...

Taking certain antidepressants in combination with the opioid pain medication tramadol was associated with an increased risk for seizures in older adults, a new study showed. Using Medicare data from ...

> Strong CYP2D6 Inhibitors* Paxil (paroxetine) > Prozac (fluoxetine) > Wellbutrin (bupropion) > Moderate CYP2D6 Inhibitors Cymbalta (duloxetine) > Zoloft (sertraline) > Weak CYP2D6 Inhibitors Celexa ...