Sen argues that “erosion of the epigenome” at cryptic sites associated with aging in senescent cells could boost spurious transcription. Although histone methylation decreased overall in senescent ...

Researchers from the University of Colorado Cancer Center have solved a cellular mystery that may lead to better therapies for colorectal and other types of cancer.

Scientists explore partial cellular reprogramming using antibiotics to reverse aging and repair cells and tissues safely.

Discover how histone modifications unlock secrets of human aging, rivaling the precision of DNA methylation in decoding ... models across tissues and cell types. Aging involves complex cellular ...

This includes investigation of nuclear organization, DNA methylation, histone modification ... propagation of cell identity without any mutational change in DNA sequence. The aging process is ...

These modifications, which include DNA methylation, histone modifications, chromatin remodeling, and RNA modifications, are crucial for maintaining cell identity ... that aging, which is ...

We have characterized the histone methylation profiles affected by this cell phenotype switch and identified Atg4b ... and myostatin in muscle repair related to aging decline (or lack thereof). The ...

Dendritic cells (DCs) actively participate in maintaining ... An age-associated modification in self-antigens, such as decreased methylation of the DNA, allows aged DCs to view them as novel ...

Using a big data approach, the researchers have developed a computer model called the "Single-Cell Immune Aging Clock," which can be used to determine aging processes within individual immune cells.

Some common measures of biological age use blood samples to measure epigenetic aging and DNA methylation, which influences the roles of genes in the cell. However, measuring biological age from blood ...