Sen argues that “erosion of the epigenome” at cryptic sites associated with aging in senescent cells could boost spurious transcription. Although histone methylation decreased overall in senescent ...

Epigenetic reprogramming holds promise for reversing aging, addressing cellular aging mechanisms and paving the way for innovative therapeutic strategies.

The scientists state that epigenetic clocks based on the entropy of methylation states predict chronological age with ...

“ […] methylation entropy is measuring different properties of a locus compared to mean methylation and CHALM, and that loci ...

Discover how histone modifications unlock secrets of human aging, rivaling the precision of DNA methylation in decoding ... models across tissues and cell types. Aging involves complex cellular ...

Dendritic cells (DCs) are critical in the maintenance ... An age-associated modification in self-antigens, such as decreased methylation of the DNA, allows aged DCs to view them as novel antigens ...

2 The collection of epigenetic marks in a cell or organism is known as its epigenome ... the most established and well-researched of which are histone modifications and DNA methylation. “What's ...

A new research paper was published in Aging (Aging-US) Volume 17, Issue 3, on March 12, 2025, titled "DNA methylation entropy is a biomarker for aging." ...