Cancer cells are subjected to high mechanical pressure that leads to a rupture of the nuclear envelope when migrating through narrow tissue structures, as in the case of metastasis. DNA would normally ...

IN his presidential address to the Royal Microscopical Society delivered on Jan. 20, Prof. R. Ruggles Gates reviewed present knowledge regarding nuclear structure, especially in relation to genetics.

Cellular mechanical states modulate cytoskeleton–nucleus links and trigger the translocation of regulatory molecules to the nucleus. The remodelling of cytoskeleton–nucleus links results in distinct ...

A hidden structure inside the cell is rewriting how scientists understand leukemia. Beneath the microscope, what looked like ...

The Kanazawa team led by Katsuya Sakai, discovered that CHD1 uses a flexible region to form tiny liquid-like droplets, called condensates, that act as hubs for controlling the activity of crucial ...

Researchers at the Kennedy Institute have provided the most comprehensive overview to date of how the distinctive segmented ...

Researchers at the Francis Crick Institute have shown that the 'pacemaker' controlling yeast cell division lies inside the nucleus rather than outside it, as previously thought. Having the pacemaker ...

AFM, which inserts a nanoneedle probe directly into cells, scientists revealed how cancer cell nuclei stiffen or soften depending on chromatin structure and environmental conditions.

Researchers of the University of Freiburg Cluster of Excellence CIBSS demonstrate that an actin scaffold stabilizes the cell nucleus upon mechanical stress. This protective mechanism helps cancer ...