Covalent chemical probes – chemical probes that form a covalent bond with their target biomacromolecule(s) represent powerful tools that can be used for biology discovery, target validation (or ...
Prior to 2000, many drugs that formed a covalent bond with targets did so non-selectively, which often led to undesired side effects when compared to non-covalent drugs. This led to the belief that ...
The discovery of a stable single-electron covalent bond between two carbon atoms validates a century-old theory. The discovery of a stable single-electron covalent bond between two carbon atoms ...
BUFFALO, N.Y. — One class of drugs that has shown promise in treating diseases ranging from lung cancer to COVID-19 are targeted covalent inhibitors (TCIs). These small molecule drugs form covalent ...
Chemists at Hokkaido University have experimentally confirmed the existence of a single-electron carbon-carbon bond for the first time (Nature 2024, DOI: 10.1038/s41586-024-07965-1). Linus Pauling ...
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