Cells sustain their purine levels through two pathways: De novo synthesis builds purines from scratch, whereas the salvaging route uses intermediate metabolites, such as those obtained from the diet.

Pyrimidine analogs, such as 5-fluorouracil (5-FU) and gemcitabine, are used as chemotherapeutic agents to treat various types of cancer. These drugs interfere with DNA synthesis and replication, ...

This image illustrates the chemical structure of a purine molecule, highlighting the numbering of the carbon and nitrogen atoms. The purine structure consists of a pyrimidine ring ... cellular ...