It is also likely that end-joining mechanisms, including NHEJ, MMEJ and SSA, play a part, especially in cells of the immune system. The breakage–fusion–bridge cycle has been shown to operate ...

Parabilis Medicines (formerly Fog Pharmaceuticals), a clinical-stage biopharmaceutical company committed to creating ...

Starting with the BCR-ABL1 gene fusion in chronic myeloid leukaemia 1 and extending to the recent report of the ETV6-NTRK3 gene fusion in congenital fibrosarcoma 2, a series of gene fusions ...

This work developed a new deep learning framework, MULGONET, to predict cancer recurrence and identify key biomarkers by integrating multi omics data (such as mRNA, DNA methylation, copy number ...

The findings, published recently in the journal Science Advances, provides valuable insights into genetic repair mechanisms that could deepen our understanding of human gene evolution.

VITRAKVI ® is now fully approved for adult and pediatric patients with solid tumors that have a neurotrophic receptor tyrosine kinase (NTRK) gene fusion without a known acquired resistance ...

In metastatic castrate-resistant prostate cancer (mCRPC) specifically, the TMPRSS2-ERG gene fusion is associated ... and circumvents known resistance mechanisms that arise in response to AR ...

“We are proud to deliver on our promise for patients with this significant step forward, providing a treatment option for pediatric and adult patients living with NTRK gene fusion-positive cancers.