The characteristics of the sample are presented in Table 1 and Table 2. The average age was 60.9 years, and patients had been diagnosed an average of 12 years. Most were male (81%), and 38% were ...

Credit: Shutterstock. The investigational drug AR882 appeared more effective and safer than allopurinol monotherapy in a phase 2 trial. A novel selective URAT1 inhibitor, AR882, further reduces serum ...

Please provide your email address to receive an email when new articles are posted on . Both excessive and long-term alcohol consumption, as well as any spirit consumption, predict the development of ...

Pegloticase quickly resolved tophi among patients with gout who responded to the treatment, according to data published in Arthritis Research & Therapy. “Pegloticase is a recombinant mammalian uricase ...

In this study, just over 15% of participants with gout for less than 10 years had tophaceous disease. Creatinine clearance was the major factor independently associated with early presentation with ...

— REDUCE 1 is a study running in parallel with REDUCE 2 to evaluate pozdeutinurad's efficacy in lowering serum urate (sUA) levels and resolution of target tophi in gout patients — SAN DIEGO, July 1, ...

Gouty tophus Gout was associated with increased risk for readmission for either a cardiovascular event or heart failure, and was associated with longer hospital stays in patients with acute coronary ...

Krystexxa, a PEGylated uric acid specific enzyme, is approved for the treatment of refractory chronic gout. One study retrospectively analyzed data from two 6-month, randomized clinical trials that ...

Bone erosion in patients with gout and tophi was associated with tophi duration, drinking history, ulceration, and serum creatinine levels. Bone erosion in patients with gout and tophi was associated ...

In one of these studies, the new product, called AR882 for the time being, reduced serum urate by 40% to 60% in dose-dependent fashion over a 12-week treatment period, whereas a placebo group showed ...

Bone erosions, which are associated with long-term damage and disability, are common in patients with gout and have been linked with specific clinical and ultrasound-detected factors, Chinese ...