By dissecting the molecular interplay between the virus and its host, the researchers identified novel strategies that HIV-1 employs to ensure its replication ... on the host cell to translate ...

This image shows the replication cycle of HIV/SIV. The virus replicates in the body's own CD4+ T helper cells. In doing so, it introduces its own genetic information into the DNA of the host cell.

or a ‘central DNA flap,’ as a component of HIV nuclear import. The retroviral replication cycle requires that retroviral nucleic acids integrate into the cellular DNA of the host cell.

They graphically represent the life cycle of HIV-1, from the initial binding of the viral particle onto a host cell (Viral Entry), through insinuation into the host cell's nucleus to spark the ...

In a ceremony held last month, the 2024 Louisa Gross Horwitz Prize was awarded to Wesley Sundquist, PhD, Leo T. and Barbara K ...

These latently infected cells are very few in number and it has thus been difficult to determine their origin and to study the molecular nature of the latent viral genome. HIV replication is ...

A new antiretroviral target has been identified that suppresses HIV-1 replication and selectively kills HIV-1-infected cells. HIV-1 is the most common type of HIV. When HIV-1 leaves infected cells, ...