This study involved 40 patients who met 3 criteria: HLA (human leukocyte antigen)-B27 positivity; less than 3 years of back pain that on history seemed inflammatory; and magnetic resonance imaging ...
Researchers have shown the endoplasmic reticulum (ER) stress pathway known as the unfolded protein response (UPR) is involved in the degradation of HLA-B27 heavy chain dimers. HLA-B27 is associated ...
The probability of developing ocular EIMs was comparable across treatment classes among patients with HLA-B27-associated diseases.
NAILS: The inflammation throughout the body from PsA and PsO can affect the nail beds as well. The symptoms can range from minor nail weakening and swelling of the nail bed to pitting (dents on the ...
Ankylosing spondylitis can create uncomfortable pain or stiffness in your back, neck, hips, and other areas of your body. We’ve learned a lot about AS in recent years but there’s still a lot we don’t ...
HLA-B27 is strongly associated with spondyloarthritis (SpA) and has been suggested to promote this disease through the aberrant initiation of immune responses. Now, Robert Colbert and colleagues have ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, No. 20 (Oct. 15, 1993), pp. 9330-9334 (5 pages) Several human rheumatic diseases occur predominately in ...
Axial disease is common and burdensome in patients with psoriatic arthritis (PsA). Human leukocyte antigen-B27 (HLA-B27) is a risk factor for axial PsA; treatment response by HLA-B27 status is ...
This case study describes an atypically severe attack of uveitis in a patient with HLA-B27-positive ankylosing spondylitis. Although TNF-inhibitor therapy was extremely effective regarding articular ...
Human leukocyte antigen (HLA) typing is important in organ transplantation protocols, as they determine the likelihood of rejection. The HLA system is little understood, however. In simple terms, the ...
If you’re Black, you may be less likely than someone who’s white to develop Ankylosing Spondylitis (AS). But if you do, it could be more severe than it would be in a white person. This type of ...
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