Epigenetics is the study of various heritable alterations that control gene expression without changing the DNA sequence ... the most established and well-researched of which are histone modifications ...

For instance, some repressors bind near the start of mRNA production for an entire operon, or cluster of coregulated ... When a specific gene is tightly bound with histone, that gene is "off." ...

Setd2 is instrumental in the trimethylation of histone H3 lysine 36 (H3K36me3), a modification that influences gene expression and ... specific 5′ Hoxa cluster genes. The study's conclusions ...