Sen and her colleagues studied fragments containing cryptic sites and compared the levels of histone methylation, which winds up DNA and switches it “off” by making it unavailable for transcription, ...

Thus, histone modifications generally represent a more complex and diverse mechanism to affect gene transcription than DNA methylation. In fact, one effect of DNA methylation can be to recruit ...

Histone modification can open chromatin, thus permitting selective binding of transcription factors ... that acetylation of histone H3 and methylation at lysine residue K4 appeared to coincide ...

Epigenetic reprogramming holds promise for reversing aging, addressing cellular aging mechanisms and paving the way for innovative therapeutic strategies.

One function of histone modifications is to make DNA more or less accessible for transcription. Heterochromatin is highly ... they regulated that way,” remarked Cosgrove. “Generally, methylation at ...

These modifications, which include DNA methylation, histone modifications ... either by directly affecting transcription factors or by influencing their response to environmental changes.

Citrullination, a transformative protein post-translational modification, is gaining recognition for its wide-ranging impact on cellular function and human disease.

Citrullination, a transformative protein post-translational modification, is gaining recognition for its wide-ranging impact ...

Epigenetic modifications, such as DNA methylation and histone modifications, can affect gene expression by altering the accessibility of DNA to transcription factors and other regulatory proteins. DNA ...