This article considers neuraminidase inhibitors, which are active against influenza virus and are crucial to planning for an influenza pandemic from a new influenza virus of any origin, including a ...

Background: Safe and effective antiviral agents are needed to prevent infection with influenza A and B virus. Oseltamivir (GS4104), which can be administered orally, is the prodrug of GS4071, a ...

Development of novel influenza neuraminidase inhibitors is critical for preparedness against influenza outbreaks. Knowledge of the neuraminidase enzymatic mechanism and transition-state analogue ...

Varghese, JN, Smith, PW, Sollis, SL, et al. Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase. Structure 1998;6: ...

Influenza vaccine development has largely focused on the hemagglutinin, but the other major surface antigen, the neuraminidase, has reemerged as a potential target for universal vaccines,” the ...

Its full scientific name is avian influenza A(H5N1), so it contains hemagglutinin 5 and neuraminidase 1. Bird flu primarily affects birds, as per the name, but has adapted to infect cows and can ...

A study published in PLOS PATHOGENS describes the prevalence and functions of mutations in neuraminidase enzyme of avian H5N1 influenza viruses that are preferentially selected in human H5N1 ...

Researchers have identified antibodies targeting a hard-to-spot region of the influenza virus, shedding light on the relatively unexplored 'dark side' of the neuraminidase (NA) protein head. The ...

Influenza A is divided into subtypes based on two proteins on the virus's surface: hemagglutinin and neuraminidase. ... (H1N1) virus, one influenza A(H3N2) virus, ...

Researchers at the National Institutes of Health have identified antibodies targeting a hard-to-spot region of the influenza virus, shedding light on the relatively unexplored “dark side” of ...