Given the enormous estimated burden of respiratory virus infections worldwide, a substantial number of research priorities exist in order to better understand their epidemiology, pathogenesis ...

Pathogenesis –- literally ... can considerably alter immune responses. A virus that replicates with a high mutation rate such as LCMV or influenza, for example, produces progeny that potentially ...

we identify a regulatory pathway by which release of the neurotransmitter acetylcholine by B cells suppresses TNF production by lung interstitial macrophages early in influenza virus infection.

Influenza viruses are among the most likely triggers of future pandemics. A research team from the Helmholtz Center for Infection Research (HZI) and the Medical Center—University of Freiburg has ...

More information: Hsiang-Chi Huang et al, Nuclear AGO2 supports influenza A virus replication through type-I interferon regulation, Nucleic Acids Research (2025). DOI: 10.1093/nar/gkaf268 Provided ...

A research team led by the School of Public Health in the LKS Faculty of Medicine, the University of Hong Kong (HKUMed), in ...

The RNP complex is the influenza virus’s essential package, the virus’s blueprints and a copy machine all rolled in one. The ...

Host immune and proinflammatory responses to respiratory virus infections play key roles in disease pathogenesis and end-organ damage in the case of severe infections. These responses are diverse ...

The influenza A virus redirects the RNA interference protein AGO2 into the cell nucleus, where it suppresses type I interferon genes, weakening immune signaling.