Osteoporosis, a disease characterized by reduced bone mass and increased skeletal fragility, affects 10 million Americans; another 34 million are at risk for it. Bisphosphonates are widely prescribed ...

This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major ...

The goal of treatment in patients with postmenopausal osteoporosis is to reduce the risk of fractures. The clinical efficacy of new drugs to treat osteoporosis must be judged in clinical trials that ...