Scientists have discovered that the internal shape of tiny drug-delivery particles—called lipid nanoparticles—has a big impact on how well our cells absorb them, paving the way to more efficient ...

To create A1 lipid nanoparticles for delivering mRNA to target cells, scientists at the University of Pennsylvania used A3 coupling. A3 refers to the amine–aldehyde–alkyne coupling reaction, which the ...

An AI-identified lipid called P1 delivered mRNA 14.8 times more efficiently than the clinically approved lipid ALC-0315. Lipid P1's unique three-dimensional conformation allows it to bind ...

Scientists from the University of Pennsylvania have developed an ideal “recipe” for ionizable lipids, which are essential components of lipid nanoparticles (LNPs), the molecules that underlie the ...

Just as a chef perfects a dish by experimenting with flavors and textures, the researchers used an iterative process, testing variations to find the ideal structure for the ionizable lipid. This lipid ...

The body has to clear away dead cells and other unnecessary or unneeded stuff, and one mechanism that is crucial to the degradation of such materials is called LC3-associated phagocytosis (LAP). This ...

Penn Engineers have cooked up a new way to improve mRNA delivery, developing an optimal “recipe” for ionizable lipids — key ingredients in lipid nanoparticles (LNPs), the molecules behind the COVID-19 ...

New experiments suggest that freezing and thawing on early Earth may have helped primitive cell-like structures grow and ...

The science of memories has been pursued and studied since the days of ancient Greece and Aristotle. Today, research ...

Penn Engineers have cooked up a new way to improve mRNA delivery, developing an optimal "recipe" for ionizable lipids—key ingredients in lipid nanoparticles (LNPs), the molecules behind the COVID-19 ...