Scientists now report that an enzyme from the extremophile Methanocaldococcus jannaschii connects unactivated sp 3-hybridized carbons at the ends of two lipid tails to create large macrocyclic ethers.

Key enzyme in lipid metabolism linked to immune system aging. ScienceDaily. Retrieved June 11, 2025 from www.sciencedaily.com / releases / 2025 / 04 / 250418112813.htm.

Using a mouse heart attack model, researchers have shown that knocking out one particular lipid-modifying enzyme, along with a short-term dietary excess of a certain lipid, can improve post-heart ...

An enzyme that helps break down cholesterol may also be a therapeutic target to stave off neurologic diseases, including Alzheimer's and a rare genetic disorder, according to a new study published ...

An enzyme that helps break down cholesterol may also be a therapeutic target to stave off neurologic diseases, including Alzheimer's and a rare genetic disorder, according to a new study published ...

A DNA nanostructure flips lipids from one side of a lipid bilayer to the other more than 1,000 times as fast as natural enzymes called scramblases, researchers report (Nat. Commun. 2018, DOI: 10. ...

Reduced ELOVL2 enzyme activity disrupts lipid balance in immune cells, leading to faster aging of the immune system and impaired B cell function. ... The lipid profiles of these mice also resembled ...

This effect arises because the key enzyme for the production of amyloid-β, the so-called γ-secretase, is localized inside the membrane. Remodeling in the cell membrane alters enzyme activity ...

Using a mouse heart attack model, Ganesh Halade, Ph.D., and his University of Alabama at Birmingham colleagues have shown that knocking out one particular lipid-modifying enzyme, along with a ...

More information: Silvia Vicenzi et al, Systemic deficits in lipid homeostasis promote aging-associated impairments in B cell progenitor development, GeroScience (2025). DOI: 10.1007/s11357-025 ...

Two immune responses are important for recovery after a heart attack—an acute inflammatory response that attracts leukocyte immune cells to remove dead tissue, followed by a resolving response ...