However, the conventional assay-development process for lipid-modifying enzymes is time consuming and tedious. Separation-based Approach. By employing a separation-based assay detection platform, ...

Scientists now report that an enzyme from the extremophile Methanocaldococcus jannaschii connects unactivated sp 3-hybridized carbons at the ends of two lipid tails to create large macrocyclic ethers.

More information: Silvia Vicenzi et al, Systemic deficits in lipid homeostasis promote aging-associated impairments in B cell progenitor development, GeroScience (2025). DOI: 10.1007/s11357-025 ...

Using a mouse heart attack model, researchers have shown that knocking out one particular lipid-modifying enzyme, along with a short-term dietary excess of a certain lipid, can improve post-heart ...

A DNA nanostructure flips lipids from one side of a lipid bilayer to the other more than 1,000 times as fast as natural enzymes called scramblases, researchers report (Nat. Commun. 2018, DOI: 10. ...

This effect arises because the key enzyme for the production of amyloid-β, the so-called γ-secretase, is localized inside the membrane. Remodeling in the cell membrane alters enzyme activity ...

An enzyme that helps break down cholesterol may also be a therapeutic target to stave off neurologic diseases, including Alzheimer's and a rare genetic disorder, according to a new study published ...

An enzyme that helps break down cholesterol may also be a therapeutic target to stave off neurologic diseases, including Alzheimer's and a rare genetic disorder, according to a new study published ...

Reduced ELOVL2 enzyme activity disrupts lipid balance in immune cells, leading to faster aging of the immune system and impaired B cell function. ... The lipid profiles of these mice also resembled ...

Key enzyme in lipid metabolism linked to immune system aging. ScienceDaily. Retrieved June 11, 2025 from www.sciencedaily.com / releases / 2025 / 04 / 250418112813.htm.

Two immune responses are important for recovery after a heart attack—an acute inflammatory response that attracts leukocyte immune cells to remove dead tissue, followed by a resolving response ...