Major targets in the search for a “universal,” or “common-epitope,” vaccine have been the highly conserved external domain of the influenza matrix 2 (M2) protein and conserved epitopes ...

In response, attention has also been directed towards the matrix-2 (M2) protein (Figure 2). This protein spans the membrane of the influenza viral particle and functions to internalize the acid I ...

The double-layered nanoparticle vaccine contains the influenza virus proteins matrix protein 2 ectodomain (M2e) and neuraminidase (NA). Mice were immunized with the nanoparticle vaccine before ...

Single-Component Multilayered Self-Assembling Protein Nanoparticles Displaying Extracellular Domains of Matrix Protein 2 as a Pan-influenza A Vaccine ...

“Single-Component Multilayered Self-Assembling Protein Nanoparticles Displaying Extracellular Domains of Matrix Protein 2 as a Pan-influenza A Vaccine” was co-authored by Keegan Braz Gomes, Yi ...

For their influenza vaccine, the researchers created an mRNA cocktail encoding the four influenza proteins neuraminidase, nucleoprotein, matrix protein 2, and the stalk portion of hemagglutinin ...

The double-layered nanoparticle vaccine contains the influenza virus proteins matrix protein 2 ectodomain (M2e) and neuraminidase (NA). Mice were immunized with the nanoparticle vaccine before ...

Segment 2 contains PB1. Some strains of influenza A may also code for PB1-F2, ... Segment 7 codes for M1 matrix protein and through RNA splicing, M2 ion channel.

Reference: Braz Gomes K, Zhang YN, Lee YZ, et al. Single-component multilayered self-assembling protein nanoparticles displaying extracellular domains of matrix protein 2 as a pan-influenza A vaccine.

Genomic analysis of the 2009 influenza A (H1N1) virus in humans indicates that it is closely related to common reassortant swine influenza A viruses isolated in North America, Europe, and Asia . 2 ...

The E protein is a small 75 amino acid transmembrane protein encoded by the human CoVs, including SARS-CoV-2. The CoVs E protein, similar to the viroporins from the influenza A virus, i.e., matrix ...