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Precision medicine treatment delivers strong results for infantile fibrosarcoma and other solid tumors
It is poised to redefine the approach to treatment for newly diagnosed fibrosarcoma and other solid tumors with the NTRK gene fusion, potentially reducing or eliminating the need for these ...
BBC5y
'Revolutionary' new class of cancer drugs approved
Getty Images Charlotte's tumour was caused by a genetic abnormality known as an NTRK gene fusion. One part of her DNA accidentally merged with another and the alteration in the blueprint for her ...
pharmaphorum8d
FDA widens label for BMS’ cancer drug Augtyro
The new indication puts Augtyro in contention with other therapies for NTRK gene fusion cancers, including Rozlytrek (entrectinib) and Bayer’s Vitrakvi (larotrectinib), which were approved for ...
pharmaphorum7d
Bayer’s Vitrakvi is first tumour-agnostic drug approved in EU
The EU drugs regulator cleared Vitrakvi (larotrectinib) for the treatment of patients with solid tumours that have an NTRK gene fusion, are locally advanced, metastatic or for whom surgical ...
ascopubs.org16d
Rate of gene fusion/rearrangement identification in GI cancers as sequencing evolved from limited panels to whole exome sequencing.
Association between skeletal muscle morphometrics and overall survival among older adults with gastrointestinal cancers. Gene rearrangements/fusions identified per year.