Fusion of macrophages is an essential step in the differentiation of osteoclasts, which play a central role in the development and remodeling of bone. Osteoclasts are important mediators of bone loss, ...

Bisphosphonates decrease bone resorption and are commonly used to treat or prevent osteoporosis. However, the effect of bisphosphonates on their target cells remains enigmatic, since in patients ...

Bone deficits are frequent in HIV-1–infected patients. We report here that osteoclasts, the cells specialized in bone resorption, are infected by HIV-1 in vivo in humanized mice and ex vivo in human ...

Researchers led by Kanazawa University show that messages sent by osteoblasts via extracellular vesicles trigger the formation of mature osteoclasts during fracture healing Kanazawa, Japan - In a ...

Panel A shows osteoclasts and osteoblasts in normal bone (toluidine blue, ×100). The large osteoclast is actively resorbing bone. Osteoblasts are small, cuboid cells that actively lay down bone matrix ...

A representative micrograph of osteoclast differentiation and activity in response to irradiation with blue light. Numerous small pits formed on the bone-like substrate in the half of the well that ...

As part of our natural bone development, special cells on the surface break down old bone tissue and then build it back up again. When changes occur to this cycle and throw things off balance, ...

Bone-dissolving cells called osteoclasts are derived from a type of immune cells called macrophages. They are necessary for the maintenance and renewal of bones. But the intracellular mechanisms ...

Tiny pieces of plastic are turning up everywhere, even inside the human body. And it may be infiltrating our bones and making ...

A new discovery about osteoporosis suggests a potential treatment target for that brittle-bone disease and for bone loss from rheumatoid arthritis. A new discovery about osteoporosis suggests a ...