GEN - Genetic Engineering and Biotechnology News2d
Structure of Key Parkinson’s Disease Protein, PINK1, Seen for First Time
Researchers say structure reveals many new ways to change PINK1, essentially switching it on, which will be "life-changing" for people with Parkinson’s disease.
Medindia2d
Structure of Human PINK1and Its Role in Parkinson's Disease
Discover PINK1 structure offers new hope for Parkinson’s disease treatment by revealing its mitochondrial interactions and ...
Technology Networks2d
Decades-Long Parkinson's Disease Mystery Solved
New research provides key insights into the structure and function of PINK1, a protein linked to Parkinson's disease.
ALZFORUM1d
Pretty in PINK1, Cryo-EM Reveals How Kinase Anchors to Mitochondria
This new cryo-EM structure represents a remarkable advance in our understanding of how human PINK1 is stabilized” said ...
Medscape26d
Understanding the Molecular Basis of Parkinson's Disease, Identification of Biomarkers and Routes to Therapy
Parkin, PINK1 and DJ-1 operate in the same pathway; they can interact to create an ubiquitin–protein ligase complex. Substrates will need to be identified in stressed cells. Parkin binds to ...
Medscape10d
Proteomic Analysis of Mitochondrial Dysfunction in Neurogenerative Diseases
2010;7(4):519-542. PARK2/PARKIN PARK2 is characterized by genetic defects in the parkin protein, an E3 ubiquitin ligase that targets misfolded proteins to the UPS. Defective parkin activity ...
Nature25d
Putting the brakes on mitochondrial fusion to prevent escape of mitochondrial DNA
However, a more-selective maintenance pathway is initiated in parallel by the proteins PINK1 and Parkin. This maintenance pathway digests individual, damaged mitochondria using a degradation ...