Researchers say structure reveals many new ways to change PINK1, essentially switching it on, which will be "life-changing" for people with Parkinson’s disease.

Discover PINK1 structure offers new hope for Parkinson’s disease treatment by revealing its mitochondrial interactions and ...

New research provides key insights into the structure and function of PINK1, a protein linked to Parkinson's disease.

This new cryo-EM structure represents a remarkable advance in our understanding of how human PINK1 is stabilized” said ...

“Our structure reveals many new ways to change ... Once attached it tags ubiquitin, which then links to a protein called Parkin so that the damaged mitochondria can be recycled.

2010;7(4):519-542. PARK2/PARKIN PARK2 is characterized by genetic defects in the parkin protein, an E3 ubiquitin ligase that targets misfolded proteins to the UPS. Defective parkin activity ...

However, a more-selective maintenance pathway is initiated in parallel by the proteins PINK1 and Parkin. This maintenance pathway digests individual, damaged mitochondria using a degradation ...