A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes. Science , 2021; 372 (6541): 516 DOI: 10.1126/science.abe6494 Cite This Page : ...

A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes, Science, April 30, 2021 ...

Purinergic signaling, mediated by extracellular purines such as ATP and adenosine, plays a role in immune regulation. Targeting purinergic receptors and enzymes involved in purine metabolism is a ...

Adenylosuccinate lyase (ADSL) deficiency is an inherited metabolic disorder that impairs purine metabolism. ADSL is a key enzyme in both the de novo synthesis and the purine nucleotide cycle ...

"We have shown that the de novo purine biosynthetic [DNPB] pathway is carried out by purinosomes consisting of at least nine enzymes acting together synergistically to increase their overall ...

For more than 40 years, scientists have hypothesized the existence of enzyme clusters, or “metabolons,” in facilitating various processes within cells. Using a novel imaging technology combined with ...

Analysis of the transport pathways. ... "These results demonstrate a pharmacologically effective axis between purine metabolism and BRD4-dependent chromatin states," explains study leader Giulio ...