Membrane proteins are key components of living cells. They constitute one-third of the ORFs of virtually all genomes, perform crucial roles, and are targeted by a huge number of drugs. When present in ...

Using a computer instead of a pipette, Jeffrey Skolnick contemplates the subtle forces that bring proteins together. His first computational forays helped decipher the quaternary structure of proteins ...

To function correctly, cellular proteins depend not only on their complex tertiary and quaternary structures, but also on their proximity to and interactions with other molecules participating in the ...

Biologists are using the newest biological detective devices to determine the structures of proteins and provide insight into the details of life from cell communication to gene activation. Argonne ...

DeepMind has predicted the structure of almost every protein so far catalogued by science, cracking one of the grand challenges of biology in just 18 months thanks to an artificial intelligence called ...

In the same way that multiple snapshots of a galloping horse provide information about how the horse moves, multiple snapshots of a protein changing shape can improve scientific understanding of that ...