Results reported in the September issue of the Journal of Thoracic Oncology, the official journal of the International Association for the Study of Lung Cancer (IASLC), revealed the RET M918T ...

Novel oncogenic RET mutation found in small cell lung ... of SCLC as no other activating mutations were identified among the 19 oncogenes assayed in the tumor harboring the RET M918T mutation, ...

Background: Medullary thyroid cancer (MTC) accounts for 1 to 2% of thyroid cancers in the United States; RET alterations occur in >95% of hereditary and 50% of sporadic forms. Up to 80% of patients ...

Somatic gain-of-function mutations in the RET ... of all MTC, which are sporadic. Depending on the method used and perhaps the region of origin, somatic RET mutations, predominantly M918T, ...

Background: Point mutations in RET tyrosine kinase, most commonly C634R and M918T, result in the development of medullary thyroid cancer (MTC). C634R and M918T occur in the cysteine-rich and kinase ...

data on OS was only available for the RET‑M918T mutation-positive subgroup in EXAM (a specific type of RET mutation) the matching-adjusted treatment comparisons were not done in the relevant ...

A total 62.5% of patients had a RET M918T mutation. Additional efficacy findings showed that the PFS benefit with the highly selective, potent RET inhibitor was also observed via investigator ...