LaBonne is president of the Society for Developmental Biology and the Erastus Otis Haven professor of molecular biosciences at Northwestern University. Imagine a world without lifesaving medicines, ...

Animal models have long shaped how biomedical research is conducted. They have influenced how diseases are studied, how risks are assessed, and how potential treatments move from early discovery ...

The recent creation of the NIH Office of Research Integrity, Validation, and Adoption of New Approach Methodologies (ORIVA) is more than just an administrative shift. It represents a historic ...

The FDA’s recent announcement to reduce, and in some cases replace, animal testing for monoclonal antibodies and other ...

As a researcher, I still remember the discomfort I felt every time I had to sacrifice laboratory animals for an experiment.

Animal models are established, important tools for preclinical safety and efficacy testing. Companies are advancing more “humanized” models to better reflect human responses, while at the same time ...

Rodents are arguably the most used animal models in biological research. However, scientists can employ alternative animal models, which often possess unique traits or adaptations, to improve their ...

A new gene therapy can reverse the effects of heart failure and restore heart function in a large animal model. The therapy increases the amount of blood the heart can pump and dramatically improves ...

A figure from the research paper shows that both the model and experimental animals learned a task at a very similar pace. A new computational model of the brain based closely on its biology and ...