Front Matter delves into the stories of science. News Features cover research trends in depth, Opinion pieces advance the debate on topics in science and science policy, Inner Workings explore cutting ...

Contributed by Ian J. Bateman; received April 20, 2024; accepted October 3, 2024; reviewed by Roy Brouwer, Catherine L. Kling, and Marije Schaafsma This contribution is part of the special series of ...

Edited by Danielle Basset, University of Pennsylvania, Philadelphia, PA; received May 2, 2024; accepted January 28, 2025, by Editorial Board Member Elizabeth A. Buffalo ...

Recent experiments have challenged the belief that glial cells, which compose at least half of brain cells, are just passive support structures. Despite this, a clear understanding of how neurons and ...

The generation of fusion kinases through gene rearrangement represents a primary mechanism of rearranged during transfection (RET) oncogenic conversion. The change of location, increased expression, ...

Heterotrimeric G proteins act as molecular switches that control cellular responses to external signals. Small molecules that selectively inhibit these proteins are essential for studying their ...

Cities experiencing elevated temperature (i.e., urban “heat island” warming), CO 2, and nitrogen deposition decades ahead of the projected average global change are regarded as the “harbingers” of the ...

The extent and impact of Early Medieval population movements on the establishment of trade and cultural networks across the North Sea have been the subject of debate for centuries. Analyzing ancient ...

In contrast to most crops, Vitis vinifera benefited little from classical breeding due to their heterozygosis. Strikingly, the main cultivated grape varieties that we see today have remained the same ...

Healthy brain function requires a delicate balance of neural excitation (E) and inhibition (I). In animals, this balance—the E/I ratio—is known to decrease with the maturation of inhibitory circuitry ...

As AI tools become increasingly prevalent in workplaces, understanding the social dynamics of AI adoption is crucial. Through four experiments with over 4,400 participants, we reveal a social penalty ...

Biomolecular condensates play important roles in cellular organization and function, but their internal structures remain poorly understood due to limitations in imaging techniques. This is true for ...