NIH’s SMaHT Network will chart trillions of somatic mutations to reveal how our DNA changes over a lifetime. In a nutshell ...

Genome editing technologies like CRISPR-Cas9 have transformed biology, medicine, and agriculture, but concerns remain about ...

In somatic (acquired) point mutations, the challenge is to quantify minute amounts of the mutant allele in the presence of a large excess of the normal allele that differs only in a single base pair.

For example, there are strong theoretical arguments that a high mutation rate can only be sustained if each deleterious allele significantly reduces fitness, and yet the cumulative load due to ...

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Protein redesign is an enzyme engineering strategy that enhances a template enzyme’s properties by introducing mutations. Although the method is broadly employed for enzyme design, finding optimal ...