A research team has uncovered a previously unknown type of immune signaling molecule—a novel compound combining histidine and ...

Historically, small molecule drugs have been precisely designed down to the atomic scale. Considering their relatively large complex structures, nanomedicines have lagged behind. Researchers argue ...

However, it has not been clear yet how exactly this protein interacts with its ligands and whether its structure changes depending on the type of molecule being transported. However, it is known ...

A team at UC San Francisco and Gladstone Institutes has developed new drug candidates that show great promise against the ...

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This structure has two helical chains each coiled round the same axis (see diagram). We have made the usual chemical assumptions, namely, that each chain consists of phosphate di-ester groups ...

Chemical insight into biological function is the holy grail of structural biology. Small molecules are central players as building blocks, effectors and probes of macromolecular structure and ...

A molecule named NM102 selectively inhibits the Mfd protein, a bacterial virulence and mutation factor, thereby disarming pathogenic bacteria without affecting beneficial microbiota.

BUTTE, Mont. — The Butte-Silver Bow Fire Department responded to a structure fire on the 200 block of South Washington Street at 11:45 p.m. The fire was quickly controlled and searches of the ...

Another reason for choosing a particular modality is that it is a team’s specialty. Strategic choices can be less about determining which modality best fits a potential target than about choosing a ...

The researchers identified the structure of this machine, the mitochondrial pyruvate carrier (MPC), and 50 years since its discovery, have shown how it operates like the lock on a canal to transport ...

ARLINGTON TOWNSHIP, Mich. — A structure fire in Van Buren County destroyed a mobile home and adjacent residential structure under construction Wednesday night. At around 10:30 p.m., the Bangor ...