A) Outline of basal ganglia anatomy in a coronal human brain section. B) UMAP clustering of nuclei from 12 brains based on snRNA-seq data. C) Wiring diagram of basal ganglia circuitry.

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We then selectively expressed hM3Ds in D1 medium spiny neurons (D1-MSNs) and found that hM3Ds was able to activate the D1-MSNs-mediated basal ganglia direct pathway and ... After being embedded in OCT ...

In the first comprehensive, cell-by-cell analysis of brain tissue from individuals with Tourette syndrome, researchers have pinpointed exactly which cells are perturbed and how they malfunction, ...

A global team has constructed the most detailed wiring diagram of a mammalian brain to date. A global collaboration of over 150 researchers has created the most detailed wiring diagram of a mammalian ...

In 1979, famed molecular biologist, Francis Crick, stated that it would be "[impossible] to create an exact wiring diagram for a cubic millimeter of brain tissue and the way all its neurons are ...

“It is no use asking for the impossible, such as, say, the exact wiring diagram for a cubic millimeter of brain tissue and the way all its neurons are firing,” Crick wrote in Scientific America ...

WASHINGTON, April 9 (Reuters) - Neuroscientists have produced the largest wiring diagram and functional map of a mammalian brain to date using tissue from a part of a mouse's cerebral cortex ...

The basal ganglia are a set of subcortical structures ... Dopaminergic medication and deep brain stimulation exert a shared therapeutic modulation of cortex-subthalamic nucleus network activity ...