De novo purine synthesis is regulated by several mechanisms beyond MYC in cancer cells 33,36. The PI3K–AKT signaling pathway promotes metabolic reprogramming in tumors and can modulate carbon ...

Tran DH, et al. De novo and salvage purine synthesis pathways across tissues and tumors. Cell. 2024;187(14):3602-3618.e20. Ali ES, Ben-Sahra I. Regulation of nucleotide metabolism in cancers and ...

EMERYVILLE, Calif.--(BUSINESS WIRE)--Ansa Biotechnologies, Inc., a pioneer of next-generation DNA synthesis, today announced the successful de novo synthesis of the world’s longest DNA ...

The de novo synthesis of purine and pyrimidine nucleotides occurs through separate pathways but shares some common intermediates. Salvage Pathway. The salvage pathway recycles preformed nucleobases ...

Background: Mycophenolate mofetil (MMF) inhibits IMPDH and disrupts de novo purine synthesis which is preferred by glioblastoma (GBM) whilst normal brain prefers resource efficient salvage pathway. A ...

Neuron-like cells created from a readily available cell line have allowed researchers to investigate how the human brain makes a metabolic building block essential for the survival of all living ...

- The next frontier in oligonucleotide synthesis is the direct synthesis of gene-length sequences. - Ansa synthesized a 1005 base long oligonucleotide with industry-leading accuracy. - Ansa will ...