Background: Mycophenolate mofetil (MMF) inhibits IMPDH and disrupts de novo purine synthesis which is preferred by glioblastoma (GBM) whilst normal brain prefers resource efficient salvage pathway. A ...

Scientists had thought that targeting de novo purine biosynthesis wouldn’t be an effective way to fight M. tuberculosis, because the bacterium can also rescue and recycle purines.

ATR activates mTORC1 by increasing phosphorylation and expression of the de novo cholesterol synthesis enzyme lanosterol synthase in cancer cells. While ... Buj R, Wang H, Wang J, Cole AR, Uboveja A, ...

Lanthipeptides are a family of ribosomally synthesized peptides that have crucial biological functions. However, due to their complicated structures, the total synthesis of lanthipeptides is ...

By designing proteins de novo scientists can more efficiently create novel therapeutics tailored for specific biological functions.

Merging synthetic organic chemistry and biotechnology, researchers have engineered Escherichia coli that can synthesize small ...

Researchers at the ICN2 and the UAB have developed a novel strategy to obtain different types of organic molecules by ...

Proteins are the workhorses of biology. They perform virtually every important function in living organisms. They store, copy and protect our DNA, digest food to give us energy, and harness this ...

All the latest science news on synthesis from Phys.org. Find the latest news, advancements, and breakthroughs.

The expeditious convergent synthesis of the potent human purine nucleoside phosphorylase inhibitor DADMe-Immucillin-G (3) ... Pieter Van der Veken, Stijn De Prol, Wim Versées, Jan Steyaert, Achiel ...

Healthline editors, dietitians, and medical integrity team members have vetted more than 100 products to decide on the best multivitamin for women.