Lanthipeptides are a family of ribosomally synthesized peptides that have crucial biological functions. However, due to their complicated structures, the total synthesis of lanthipeptides is ...

“AlphaDesign represents a new level of control in computational biology: the ability to generate new proteins with measurable, targeted function. This work demonstrates that AI can go beyond ...

This paper addresses a fundamental question: Can natural chaperones fold mirror-image proteins? Mirror-image proteins (composed of d -amino acids) are only accessible by chemical synthesis, but are ...

Mechanistically, ATR promotes de novo cholesterol synthesis and mTORC1 activation through the phosphorylation and upregulation of lanosterol synthase (LSS), independently of both CHK1 and the TSC ...

Although many researchers have reported that copper chloride is an important catalyst that generates relatively large amounts of dioxins in heat experiments involving model fly ash, details on the ...

Background: Mycophenolate mofetil (MMF) inhibits IMPDH and disrupts de novo purine synthesis which is preferred by glioblastoma (GBM) whilst normal brain prefers resource efficient salvage pathway. A ...