Small molecule ligands exhibit a diverse range of conformations ... While refinement improves the correlation between the model and the electron density map, it may inadvertently increase strain ...

In 1977, the Nobel Prize in Physiology or Medicine was awarded to Roger Guillemin and Andrew Schally for their discovery and synthesis of gonadotropin-releasing hormone (GnRH), a key regulator of ...

BRISBANE, Australia & CAMBRIDGE, Mass.--(BUSINESS WIRE)--Vaxxas, a clinical-stage biotechnology company, today announced it has completed enrollment for its Phase I clinical trial of a vaccine against ...

In α-synuclein fibrils from people with multiple system atrophy, for example, researchers have identified a structure not observed in lab-grown fibrils. In the fibrils from brains, electron density ...

We introduce DiffFit, a differentiable algorithm for fitting protein atomistic structures into an experimental reconstructed Cryo-Electron Microscopy (cryo-EM) volume map. In structural biology, this ...

Department of Computer Science, Old Dominion University, Norfolk, VA, United States; Although cryo-electron microscopy (cryo-EM) has been successfully used to derive atomic structures for many ...

1 Theoretical Molecular Science Laboratory, RIKEN Cluster for Pioneering Research, Wako-shi, Japan; 2 RIKEN Center for Computational Science, Kobe, Japan; 3 RIKEN Center for Biosystems Dynamics ...

Researchers employed the gold electrode and attached the target molecules onto the electrode. Just like functional groups generate diverse electronic effects, one electrode fits all reactions as ...

Researchers map the molecular structure of wood in bid to make it more resilient "If we can increase the strength of wood, we may start seeing more major constructions moving away from steel and ...

A combined experimental and theoretical study at the Max Born Institute Berlin investigated the strong-field driven electron recollision dynamics in the 1,3-trans-butadiene molecule.