The summaries of product characteristics (SmPCs; previously called data sheets) of certain drugs sometimes specify that they should be used “at the discretion of the physician,” often when advising ...

1 Orthopaedic Department, Affiliated ZhongShan Hospital of Dalian University, Dalian, Liaoning, China 2 Orthopaedic Medical Research Center, Dalian University, Dalian, Liaoning, China Bone defects ...