"Successful self-replication under no human assistance is the essential step for AI to outsmart [humans], and is an early signal for rogue AIs," the researchers wrote in the study, published Dec ...

Moreover, this finding underscores IPO7’s essential function in the flavivirus life cycle, specifically in the later stages of viral particle assembly and release. The study’s findings suggest that ...

During infection, flavivirus core proteins migrate to the nucleus of host cells to aid viral replication. Researchers have identified a transporter protein, called importin-7 (IPO7), as crucial for ...

Researchers then tested how removing IPO7 affected virus production by infecting cells with flavivirus. Cells without IPO7 produced fewer viral particles, even though both cell types had similar virus ...

Researchers have identified IPO7 as a carrier of flavivirus core protein into host cell nucleus, paving the way for a new therapeutic approach to a range of diseases. view more Credit: Professor ...

As positive-sense RNA viruses, the genomes of flaviviruses serve as the template for all stages of the viral life cycle, including translation, replication, and infectious particle production. Yet, ...

TBE: Activation mechanism of flaviviruses identified Molecular switch controls the processes of virus assembly, virus maturation and entry into new cells Peer-Reviewed Publication ...

Because of their close relationship and structural homology, the insights gained from the TBE virus model are valid for all flaviviruses, including several major mosquito-borne viruses (e.g ...

Flavivirus replication cycle. Flavivirus infection begins by receptor-mediated binding to the host cell and entry via clathrin-mediated endocytosis. Decreases in endosome pH trigger virion envelope ...

Alphaviruses and flaviviruses have class II fusion glycoproteins that are essential for virion assembly and infectivity. Importantly, the tip of domain II is structurally conserved between the ...