E.g. dwarfness is suppressed by tallness. b) Homozygous – Genotype comprising of similar allele. E.g. tt or TT Heterozygous – Genotype comprising contrasting allele. E.g. Tt c) Monohybrid ...

CRISPR-Cas9 gene editing yielded both OPA1 homozygous and heterozygous mutant ESC lines from a parental control ESC line. In addition, CRISPR-mediated homology-directed repair (HDR) successfully ...

This is an important study utilizing innovative CRISPR based approaches demonstrating the role of the KLF family of transcription factors in the post natal maturation of cortical projection neurons.

Nat Clin Pract Neurol. 2006;2(9):482-493.