Partial hepatectomy did not affect serum ALT levels in animals that received lentivirus (Fig. 3). The observed liver injury may be a direct toxic effect of the viral particles or contaminants in ...

In the original lentivirus vectors described by Naldini et al (Naldini et al., 1996a) (Naldini et al., 1996b) , the vector pCMVΔR8.2 supplies all but the HIV envelope in trans, the vector pMD.G is ...

Among these, lentivirus-based vectors, derived from the HIV-1 retrovirus, are of growing interest in gene and cell therapy, particularly in immuno-oncology, due to their ability to infect dividing ...

The trial will test four dose levels and include up to 18 patients with advanced, FLT3-expressing acute myeloid leukemia.