An engineered protein turns off the kind of immune cells most likely to damage tissue as part of type-1 diabetes, hepatitis, ...

The development of a cross-protective pan-influenza A vaccine remains a significant challenge. In this study, we designed and evaluated single-component self-assembling protein nanoparticles (SApNPs) ...

To fabricate influenza vaccine NPs, the tetrameric chimeric influenza A virus matrix protein 2 ectodomain (M2e) was desolvated to form nanoclusters, which were then surface functionalized with ...

Animal protein intake is associated with an increased risk of type 2 diabetes, according to a new meta-analysis of prospective studies including over 600,000 people. 1 Every 20-gram increase in animal ...

“Single-Component Multilayered Self-Assembling Protein Nanoparticles Displaying Extracellular Domains of Matrix Protein 2 as a Pan-influenza A Vaccine” was co-authored by Keegan Braz Gomes, Yi ...

In this study, Longhorn examined mice that were immunized with 20µg of Covid-19 Pep05 (Covid-19 POL and influenza NA+Matrix (M1/M2)) and Covid-19 Pep11 (Covid-19 SP and influenza NA+Matrix (M1/M2 ...

First, recent studies have examined the distribution of influenza virus transcription or protein expression across differentiated airway cells ex vivo (Yamawaki et al., 2021; Kelly et al., 2020; Wang ...

Another promising target is Matrix Protein 2, or M2. M2 is highly conserved among different influenza strains, making it an attractive target for universal vaccines.

In response, attention has also been directed towards the matrix-2 (M2) protein (Figure 2). This protein spans the membrane of the influenza viral particle and functions to internalize the acid I ...

Here, we assessed the immunogenicity and protective efficacy of nucleoside-modified mRNA-LNP vaccines that contain four influenza A group 2 virus antigens (hemagglutinin stalk, neuraminidase, matrix ...

The E protein is a small 75 amino acid transmembrane protein encoded by the human CoVs, including SARS-CoV-2. The CoVs E protein, similar to the viroporins from the influenza A virus, i.e., matrix ...