This fundamental study combines in vitro reconstitution experiments and molecular dynamics simulations to elucidate how membrane lipids are transported from the outer to the inner membrane of ...

Metabolism and Metabolic Flexibility in the Aging Heart OXPHOS is the main energy ... whether by manipulation of the mitochondrial proteome, modulation of electron transport, activation of biogenesis ...

ETF insufficiency caused by decreased ETFDH expression limits flexibility of OXPHOS fuel utilization but paradoxically ... with BCL-6-dependent reduction in 4E-BP1 levels to drive mitochondrial ...

Mitochondrial enzymatic activity and mtDNA density measures display low between-tissue correlations across 22 tissues from 27 mice. A long-standing assumption is that mitochondrial energy capacity ...

This paper was supported by National Natural Science Foundation of China (Grant/award Numbers: 32225047, 82160389); Double first-class discipline promotion project, (Grant/award Number: 2023B10564001) ...

Since the discovery that mitochondrial membrane permeabilization represents a critical step in the regulation of intrinsic apoptosis, mitochondria have been viewed as pluripotent organelles, ...

Expression of proteins regulating mitochondrial biogenesis and content. Credit: Journal of Cachexia, Sarcopenia and Muscle (2025). DOI: 10.1002/jcsm.13763 ...

Mitochondrial diseases affect approximately 1 in 5,000 people worldwide, causing debilitating symptoms ranging from muscle weakness to stroke-like episodes. Some of these conditions result from ...

Deubiquitinating Enzymes Regulate Skeletal Muscle Mitochondrial Quality Control and Insulin Sensitivity in Patients With Type 2 Diabetes. Journal of Cachexia, Sarcopenia and Muscle , 2025; 16 (2 ...

Scientists found a compound that appears to counter common mutations behind POLG-related diseases, rare conditions that harm mitochondrial DNA. Comments ( 0 ) ( ) ...