Now, NIBIB-funded researchers have found a way to model the human neuromuscular junction by growing these synapses in a lab, which could accelerate novel treatments for neuromuscular diseases.

To establish the 2D self-organizing neuromuscular junction model, the researchers first had to understand how motor neurons and muscle cells develop in the embryo. “We tested a number of hypotheses.

Alessia Urzi et al. (2023): “Efficient generation of a self-organizing neuromuscular junction model from human pluripotent stem cells”, Nature Communications, DOI: 10.1038/s41467-023-43781-3 .

The model contains neurons, muscle cells, and the chemical synapse named neuromuscular junction that is needed for the two types of cells to interact. The researchers have now published their ...

ORLANDO, Fla.--(BUSINESS WIRE)--Hesperos, Inc. has increased its pioneering human-on-a-chip drug testing capabilities by adding a new in vitro, human-human neuromuscular model to its patented ...

The first functional stem-cell derived neuromuscular junction model has recently been licensed, which could help the quest to develop new drugs to treat associated neurodegenerative diseases. We ...

Curi Bio, Genetox, and DreamCIS Sign MOU for Strategic Collaboration on 3D Neuromuscular Junction Model for Botox Potency Assay. Business Wire . Thu, Feb 22, 2024, 12:00 PM 5 min read.

Results from the MPS disease model indicated a significant reduction in the number of functional neuromuscular junctions (NMJ’s), stability of those NMJ’s that did form, and an increased ...

The effects of VCA-894A were confirmed in Hesperos' Human-on-a-Chip ® neuromuscular junction model with patient-derived cells where VCA-894A demonstrated significant improvements in neuromuscular ...

Company presented clinical and preclinical data at the MDA Conference last week in Dallas, Texas Oral presentation included data from MuSK-MG rat model depicting increases in muscle function and ...