Chemical modification describes the modification, addition or removal, through chemical reaction, of any of a variety of macromolecules, including proteins and nucleic acids. It refers to the use ...

Alkanediols such as 1,6-hexanediol disrupt many phase-separated condensates in cellula and in vitro, but how molecular interactions are perturbed by these compounds remains unclear. This study uses ...

Historically, small molecule drugs have been precisely designed down to the atomic scale. Considering their relatively large complex structures, nanomedicines have lagged behind. Researchers argue ...

This useful study reports a method to detect and analyze a novel post-translational modification, lysine acetoacetylation (Kacac), finding it regulates protein metabolism pathways. The study unveils ...

Bin Wu, associate professor in the department of Biophysics and Biophysical Chemistry at the School of Medicine, visited ...

Pyruvate in turn is used in amino acid I synthesis, gluconeogenesis as well in mixed acid fermentation. Gluconeogenesis I results in the biosynthesis of glucose from other non-carbohydrate sources, ...

School of Mechanical Engineering, Purdue University, West Lafayette, Indiana 47907, United States ...