Nucleic acids (DNA or RNA) are polymers of nucleotides – each nucleotide consists of a pentose sugar, a phosphate group and one of the nitrogenous bases (purines and pyrimidines). Nucleic acids ...

Electrochemical DNA biosensors detect the redox signal of the target analytes or a hybridization of a specific single-stranded DNA (ssDNA) sequence with its complementary strand, which are accumulated ...

Free radicals can react with all segments of the DNA molecule (both the purine and pyrimidine bases and also the deoxyribose backbone). Genetic changes resulting from these ROS induced oxidative ...

The cell NAD+/NADH ratio can constrain biomass synthesis and influence proliferation in nutrient-limited environments. However, which cell processes regulate the NAD+/NADH ratio is not known. Here, we ...

A base-mediated three-component tandem reaction for the synthesis of multisubstituted pyrimidines from amidines, aryl alkynes, and aldehydes in a one-pot manner has been developed. Advantages of this ...

Leflunomide is a selective inhibitor of de novo pyrimidine synthesis. In phase II and III clinical trials of active rheumatoid arthritis, leflunomide was shown to improve primary and secondary outcome ...

Febuxostat demonstrates greater efficacy than allopurinol in inhibiting XO and reducing SUA levels. It does not noticeably affect other enzymes involved in purine and pyrimidine metabolism. Febuxostat ...