Recordings were made from PV interneurons and pyramidal neurons in the prelimbic subregion of the mPFC. At 16 weeks of age, PV cell resting membrane potential, rheobase and action potential frequency ...

The brain contains billions of nerve cells (i.e., neurons) which receive and integrate signals from the environment and govern the body's responses. This is made possible by synapses - contacts ...

Scn1a haploinsufficiency affects CA1 pyramidal cells during early development, thereby contributing to the pathophysiology of Dravet syndrome, according to a new study published in the peer-reviewed ...

Key takeaways: Cell transformation begins with slow degeneration and progresses rapidly. The data confirmed results from previous studies of Alzheimer’s-related cell pathology.

For pyramidal cells, there was no difference in the percentage of cells significantly entrained to theta while rats were still (sham=71.57%, injured=67.17%, p=0.454, Fisher’s exact test) or moving ...

Renal cell carcinoma (RCC) is one of the 10 most commonly diagnosed solid tumors. Most RCCs are histologically defined as clear cell, comprising approximately 75% of diagnoses. However, the remaining ...

Drs Peter Martin and Eric Hsi have a thought-provoking discussion on key topics in the pathology of mantle cell lymphoma, including biopsies, diagnostic markers, and what the future holds for ...

Motor disturbances are observed in schizophrenia patients, but the neuroanatomical background is unknown. Our aim was to investigate the pyramidal cells of the primary motor cortex (BA 4) in both ...

More information: Simon Musall et al, Pyramidal cell types drive functionally distinct cortical activity patterns during decision-making, Nature Neuroscience (2023). DOI: 10.1038/s41593-022-01245-9 ...

First author Stella Glasauer used induced pluripotent stem cells made from three people with heterozygous V337M tau mutations, two with heterozygous R406W, and one with homozygous R406W to generate ...

In addition, other regions such as the pyramidal cell band of the CA, the WM, and the EC can easily be located. Identification of these regions is important in view of subsequent extraction of further ...